51 claims checked against research: 6 contradicted 1 overstated 3 needing context 37 supported 4 unverified
"When I arrived at MIT, it had just been discovered that there was a gene called SIR4 that when it was mutated would make the yeast cells live longer." (said at 0:05:06)
No published record matching the claim that a mutation in the yeast SIR4 gene extends replicative lifespan was located; this does not prove the claim false.
"We showed that sirtuins and mTOR are talking to each other." (said at 0:10:30)
No published record matching the claim that sirtuins and mTOR pathways engage in direct cross-talk and regulate each other was located; this does not prove the claim false.
"that at the same dose, NMN will increase endurance, and I forget what that dose was, it might have been 200 or 250. NR did not increase endurance, but NMN did. We do find that for some parameters, and Matt Kaeberlein, who I mentioned earlier, who works on dog aging now after doing the sirtuin extension lifespan, so Matt also has published that comparing NR and NMN, only NMN worked in his disease model, which was a mitochondrial disease" (said at 0:55:38)
No published record matching the claim that equimolar NMN increased mouse endurance while NR did not, or that Matt Kaeberlein published findings demonstrating that only NMN worked compared to NR in his mitochondrial disease model, was located; this does not prove the claim false.
"We now have a mouse that's mutant for the resveratrol activation of SIRT1, so we now see that some aspects, like endurance, of resveratrol seem to be through SIRT1. So one of the effects is through SIRT1's anti-inflammatory actions in the lining of the blood vessels, the endothelial cells... Infiltration of macrophages in there seems to be dampened, and we also looked at oxidative stress in those arteries of those mice treated, and it was way down in those resveratrol mice." (said at 0:46:25)
No published record matching the specific claim that resveratrol requires SIRT1 activation for its endurance-enhancing effects via endothelial anti-inflammatory actions and reduced arterial macrophage infiltration and oxidative stress in mutant mice was located; this does not prove the claim false.