“Bodybuilding Destroyed My Hormones”: Jesse James West on Longevity, Fitness, and Self-Worth

0:58:33 Bryan Johnson (host)supportedhigh

Drinking mineralized liquid, such as electrolyte water or salted tea, causes less frequent urination than drinking plain, unmineralized water.

"You know, if you mineralize the liquid, it has less of an effect. So either if you have salt in tea or electrolytes. If you drink straight water, it's not as mineralized, then you will urinate more." (said at 0:58:33)

Randomized crossover trials consistently demonstrate that adding electrolytes (particularly sodium) to water or consuming mineralized/electrolyte solutions leads to lower cumulative urine volume and greater fluid retention compared to drinking plain water. Ingesting large volumes of plain water rapidly decreases plasma osmolality, which suppresses antidiuretic hormone (vasopressin) and triggers a transient diuresis. In contrast, electrolyte-containing beverages maintain serum osmolality, attenuating the diuretic response and reducing post-ingestion urine output.

supports: A randomized trial to assess the potential of different beverages to affect hydration stat… (The American journal of clinical nutrition 2016) · cited 141x in the literature
"Total urine masses (mean ± SD) over 4 h were smaller than the still-water control (1337 ± 330 g) after an oral rehydration solution (ORS) (1038 ± 333 g, P < 0.001)..." (abstract, results)
pubmed full study (doi)
supports: Impact of Nuun Electrolyte Tablets on Fluid Balance in Active Men and Women. (Nutrients 2020) · cited 10x in the literature
"Nuun tablets resulted in a lower urine output compared to water, with fluid balances for both concentrations more favorable compared to water ( p < 0.05), beginning at 2 h post-ingestion and continuing at the 3 h and 4 h times." (abstract, results, passage verified)
pubmed full study (doi)
supports: Factors influencing the restoration of fluid and electrolyte balance after exercise in the… (British journal of sports medicine 1997) · cited 122x in the literature
"Ingestion of large volumes of plain water will inhibit thirst and will also promote a diuretic response. If effective rehydration is to be maintained for some hours after fluid ingestion, drinks should contain moderately high levels of sodium..." (abstract, results, passage verified)
pubmed full study (doi)

0:59:20 Bryan Johnson (host)supportedmoderate

Urinary stream speed and peak urine flow rate naturally decline with biological age.

"Your capacity, but also it gives you a biological age, because you know urine speed is biologically aged. So as you age, your urine stream decreases in overall capacity." (said at 0:59:20)

Extensive urodynamic literature and uroflowmetry nomograms confirm that peak urinary flow rate (Qmax) and urinary stream velocity progressively decline with advancing age in adults, particularly in men due to progressive detrusor changes and prostatic growth. Observational and urodynamic studies consistently demonstrate a negative correlation between chronological age and maximum flow rate.

supports: Age, gender, and voided volume dependency of peak urinary flow rate and uroflowmetry nomog… (Indian journal of urology : IJU : journal of the Urological Society of India 2009) · cited 49x in the literature
"Qmax values in adult males were significantly higher than in the elderly and Qmax values in young females were significantly higher than in young males. Qmax values in males increased with age until 15 years old; followed by a slow decline until reaching 50 years old followed by a rapid decline after 50 years old even after correcting voided volume." (abstract, results, passage verified)
pubmed full study (doi)
supports: Reassessing Normal Voiding Standards: A Cross-Sectional Study Based on Medical Professiona… (Journal of clinical medicine 2024) · cited 8x in the literature
"Notably, women exhibited higher Q max and Q ave rates irrespective of their IPSS scores, contrasting with men whose flow rates declined with age and LUTS severity." (abstract, results, passage verified)
pubmed full study (doi)

“Bodybuilding Destroyed My Hormones”: Jesse James West on Longevity, Fitness, and Self-Worth

Supported by research

Drinking mineralized liquid, such as electrolyte water or salted tea, causes less frequent urination than drinking plain, unmineralized water.

Urinary stream speed and peak urine flow rate naturally decline with biological age.