Vitamin D Expert: The Supplement World Is Giving The WRONG Advice! | Dr Stasha Gominak

Vitamin D synthesized naturally in the skin is sulfated, unlike supplemental vitamin D.

"There is a lot of literature by a gal named Stephanie Seneff who says that the vitamin D that we make on our skin is sulfated, which is different than the vitamin D we're taking as supplement." (said at 1:32:14)

Established biochemistry and photobiology demonstrate that cutaneous vitamin D synthesis occurs via UVB-induced photolysis of 7-dehydrocholesterol to previtamin D3, which thermally isomerizes into cholecalciferol (vitamin D3)—chemically identical to supplemental cholecalciferol. While computer scientist Stephanie Seneff has published speculative, non-empirical hypotheses proposing that cutaneous synthesis produces vitamin D sulfate, no validated scientific literature or experimental evidence demonstrates that natural skin synthesis produces sulfated vitamin D or that it differs chemically from standard supplemental vitamin D3.

In a clinical case, a patient (Madeline) taking 30,000 IU of vitamin D daily for 4 years maintained serum 25-hydroxyvitamin D levels in the 60s ng/mL while experiencing resolution of extremity neuropathy pain and depression.

"Madeline is struggling with all these things. She's slowly getting better. Then we do the D, she's slowly getting better. Then we do the B100. And then it's freaking awesome. She starts to lose the pain that she had down her leg. The burning in her hands and feet goes away. Her sleep gets much better. Now, she's into year three and four of what becomes the RightSleep program. And she's still on 30,000 IUs of D a day... Her D level has stayed the same. It's in the 60s... Her depression is gone. She's stopped three medicines that we've been using for pain control." (said at 1:11:12)

No published case report or formal clinical trial documenting the specific patient case ('Madeline') taking 30,000 IU/day of vitamin D for 4 years with resolution of neuropathy pain and depression could be located in PubMed or Europe PMC. The clinician (Dr. Stasha Gominak) has published theoretical hypothesis papers in Medical Hypotheses describing uncontrolled clinical observations of vitamin D (targeting serum levels of 60-80 ng/mL) and B-complex supplementation in patients with neurologic and sleep disorders, but the specific patient narrative is an unpublished clinical anecdote.

• context: The world epidemic of sleep disorders is linked to vitamin D deficiency. (Medical hypotheses 2012) · cited 140x in the literature

  "An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow range of 25(OH) vitamin D3 blood levels of 60-80 ng/ml." (abstract, results, passage verified)

  pubmedfull study (doi)
• context: Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in th… (Medical hypotheses 2016) · cited 126x in the literature

  "Vitamin D blood levels of 60-80ng/ml promote normal sleep... In order to test the hypothesis that vitamin D replacement slowly induced a secondary pantothenic acid deficiency, B100 (100mg of all B vitamins except 100mcg of B12 and biotin and 400mcg of folate) was added to vitamin D supplementation. Vitamin D and B100 were recommended to over 1000 neurology patients." (abstract, results)

  pubmedfull study (doi)

Excessive doses of supplemental B vitamins can cause sleep disruption and pain once the intestinal microbiome has normalized.

"Both sleep disruption and pain can be caused by large doses of B vitamins once the intestinal microbiome has returned to normal." (said at 1:20:43)

The claim originates from a speculative clinical hypothesis by Dr. Stasha Gominak published in the journal Medical Hypotheses (PMID 27515213), based on uncontrolled observations in neurology patients given vitamin D and B-complex supplements (B100). The paper hypothesizes relationships between vitamin D, gut bacterial B-vitamin synthesis, sleep regulation, and pain pathways. However, there are no published controlled trials or rigorous mechanistic studies establishing that excessive B-vitamin supplementation causes sleep disruption or pain specifically secondary to the normalization of the intestinal microbiome.

• context: Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in th… (Medical hypotheses 2016) · cited 126x in the literature

  "Three months of vitamin D plus B100 resulted in improved sleep, reduced pain and unexpected resolution of bowel symptoms. These results suggest that the combination of vitamin D plus B100 creates an intestinal environment that favors the return of the four specific species, Actinobacteria, Bacteroidetes, Firmicutes and Proteobacteria that make up the normal human microbiome." (abstract, results and conclusions, passage verified)

  pubmedfull study (doi)

According to USA Today, 90% of Americans spend close to 22 hours inside daily, and roughly 20% never go outside, regularly spending 24 hours indoors.

"There's some interesting stats I found which says that 90% of Americans spend close to 22 hours inside every day. That was from USA Today. And roughly 20% of Americans never go outside, regularly spending 24 hours indoors." (said at 1:37:14)

No matching publication or survey data could be retrieved from the database to confirm the exact figures cited from USA Today (that 90% of Americans spend close to 22 hours inside daily and roughly 20% never go outside / spend 24 hours indoors). While widely publicized figures from sources such as the National Human Activity Pattern Survey (NHAPS) indicate Americans spend on average roughly 87% of their time in enclosed buildings and 6% in vehicles (~22 hours total inside), the specific statistical breakdown stated by the host could not be verified in the retrieved scientific literature.