FoundMyFitness · 2016-04-09 · Rhonda Patrick (host), Dominic D'Agostino
Dominic D'Agostino, Ph.D. on Modified Atkins Diet, Keto-Adaptation, Ketosis & More
56 claims checked against research: 2 contradicted 3 overstated 5 needing context 39 supported 7 unverified
7 No source found (not proven false)
Endotoxin release increases VLDL production because VLDL binds endotoxin, and endotoxin binds to ApoB and blocks LDL receptor recycling.
"Endotoxin released from the gut, one, it causes more VLDL production because VLDL soaks it up, so that's part of the reason why inflammation is also correlated with an increase in LDL, remember. It also binds to ApoB, it binds to where the LDL receptors bind so that LDL can't be recycled as well, so it kind of prevents—there's a lot of bad things about endotoxin being released." (said at 0:18:56)
No published record matching the claim that gut-derived endotoxin directly binds to ApoB at the LDL receptor binding site to block LDL receptor recycling, or that VLDL production increases because VLDL binds and soaks up endotoxin, was located; this does not prove the claim false.
Medium-chain fatty acids directly cross the blood-brain barrier and can be oxidized directly for fuel by the brain.
"Interestingly, we had a diet, too, that was high in medium-chain fatty acids, and although I heard medium-chain fatty acids could readily cross the blood-brain barrier—long-chain fatty acids typically don't, short-chain fatty acids sort of do—but we found very high levels of medium-chain fatty acids indicative of them, and these were normal, healthy animals. So when you take medium-chain fatty acids, they are readily—from the looks of our metabolomic data, just readily crossing the blood-brain barrier and capable of being used as fuel... So they're used—medium-chain fatty acids can be oxidized just for fuel, yeah, oxidative." (said at 0:40:20)
No published record matching the claim that medium-chain fatty acids directly cross the blood-brain barrier and can be oxidized directly for fuel by the brain was located; this does not prove the claim false.
Elevating ketone levels significantly elevates blood levels of adenosine, a potent vasodilator.
"We did laser Doppler blood flow measurement and showed that it spiked up considerably when we elevate ketones. One of the things—it was not dependent upon VEGF, so we looked at all the different factors. VEGF was not increased in the wound. And we looked at a couple other things that we thought would be increased. The one thing that stood out in the data was adenosine. So adenosine levels are significantly elevated... Regardless, adenosine is a very powerful vasodilator, and it's in significantly higher concentration in the blood, and that may be increasing the perfusion of tissues, peripheral tissues." (said at 0:45:41)
No published record matching the claim that elevating ketone levels significantly elevates blood levels of adenosine to promote vasodilation and tissue perfusion was located; this does not prove the claim false.
Ketone bodies readily cross the blood-brain barrier up to concentrations of approximately 5 to 7 millimolar before transport capacity becomes saturated.
"It's thought up to 5 millimolar, maybe 6, 7 millimolar, they can readily cross the blood-brain barrier.
[0:40:12] HOST: You have to get that high before they start crossing?
[0:40:14] GUEST1: No, like you start impeding once you get levels up that high." (said at 0:40:06)
No published record matching the claim that ketone body transport across the blood-brain barrier becomes saturated specifically at concentrations of approximately 5 to 7 millimolar was located; this does not prove the claim false.
Hereditary genetic factors account for approximately 7% to 10% of all cancers.
"the most we can link hereditary effect to to cancer is maybe about 10%, you know, 7% I think was the number that was is being thrown thrown around now, but about 10% of cancers are from a hereditary" (said at 1:09:00)
No published record matching the claim that hereditary genetic factors account for approximately 7% to 10% of all cancers was located; this does not prove the claim false.
Mitochondrial DNA has less robust DNA repair mechanisms and a higher density of coding regions compared to nuclear DNA.
"mitochondria have less uh of a robust DNA repair mechanism, and also the the DNA of the mitochondria have more coding regions." (said at 1:09:47)
No published record matching the claim that mitochondrial DNA has less robust DNA repair mechanisms and a higher density of coding regions compared to nuclear DNA was located; this does not prove the claim false.
MCT powder allows individuals to achieve blood ketone levels approximately twice as high as liquid MCT oil due to superior gastrointestinal tolerance and sustained release.
"the MCT powder uh I found was is you can get levels about twice as higher than you can with the oil, just simply because your GI tolerance is much better in a powder form. So it's formulated in a way that kind of allows a sustained, slower release of the MCT instead of uh a liquid" (said at 1:44:20)
No published record matching the claim that medium-chain triglyceride (MCT) powder produces blood ketone levels approximately twice as high as liquid MCT oil due to improved gastrointestinal tolerance and sustained release was located; this does not prove the claim false.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.