AG1 NextGen is backed by four clinical trials that demonstrated it fills nutrient gaps, improves key nutrient levels within 3 months, and increases healthy gut bacteria tenfold, even among people with a good diet.
"And now they've taken it a step further with AG1 NextGen, backed by four clinical trials. And in those trials, it was shown to fill common nutrient gaps, improve key nutrient levels in just 3 months, and increase healthy gut bacteria by 10 times, even in people who already eat well." (said at 0:38:40)
The host's claim contains multiple exaggerations relative to the published clinical trials on AG1 supplementation: 1. **Trial duration and timeframe**: The claim states that AG1 improves key nutrient levels "in just 3 months." However, published human trials on AG1 evaluated acute absorption over 480 minutes (8 hours) [PMID: 42518997], 14-day supplementation [PMID: 41988471], and 4-week supplementation [PMID: 39352252]. None of the published clinical trials evaluated 3-month outcomes. 2. **Microbiome findings**: The claim asserts that AG1 "increases healthy gut bacteria by 10 times." Published clinical trials show selective enrichment of specific probiotic taxa (such as *Lactiplantibacillus plantarum*, *Lacticaseibacillus rhamnosus*, *Bifidobacterium animalis*, *Lactobacillus acidophilus*, and *Bifidobacterium bifidum*) after 14 days or 4 weeks without major changes to overall alpha or beta diversity [PMID: 41988471, PMID: 39352252]; a 10-fold (1000%) increase in healthy gut bacteria is not documented in human trials. 3. **Dietary status and nutrient gaps**: Published trials demonstrate that short-term AG1 supplementation acutely increases plasma micronutrients [PMID: 42518997] and reduces nutrient gaps by improving Estimated Average Requirement (EAR) attainment in healthy, resistance-trained adults eating standard diets [PMID: 41988471]. Overall, while published randomized clinical trials do support AG1's ability to fill nutrient gaps, elevate circulating nutrient levels, and selectively enrich specific beneficial gut taxa in active/healthy populations, the timeframe ("3 months") and magnitude of effect ("10 times") claimed by the host are unsupported exaggerations of the published clinical trial data.
- partial: The effects of AG1® supplementation on the gut microbiome of healthy adults: a randomized,… (Journal of the International Society of Sports Nutrition 2024)
"Using a double-blind, randomized, two-arm, placebo-controlled, parallel design, we examined a 4-week daily supplementation regimen of AG1 Ⓡ vs. placebo (PL)... AG1 Ⓡ supplementation enriched two probiotic taxa ( Lactobacillus acidophilus and Bifidobacterium bifidum ) that likely stem from the probiotics species that exist in the product" (abstract, methods and results)
pubmedfull study (doi) - partial: Effect of AG1 ® supplementation on nutritional adequacy and gut microbial composition in t… (Frontiers in nutrition 2026)
"AG1 ® supplementation significantly improved nutritional adequacy by increasing the total number of micronutrient Estimated Average Requirements (EARs) met compared to placebo (2.8; p = 0.0011)... AG1 ® did not produce large, global shifts in microbial alpha or beta diversity, supplementation was associated with selective enrichment of key bacterial taxa commonly linked to gut health" (abstract, results)
pubmedfull study (doi) - supports: Absorption kinetics of vitamins and minerals from a novel nutritional product in physicall… (Frontiers in nutrition 2026)
"Acute consumption of AG1 resulted in measurable increases in circulating levels of most of the tested micronutrients, indicating effective absorption." (abstract, conclusions, passage verified)
pubmedfull study (doi)