FoundMyFitness · 2016-05-03 · Rhonda Patrick (host), Ray Cronise
Ray Cronise on Cold Thermogenesis, Intermittent Fasting, Weight Loss & Healthspan
47 claims checked against research: 8 contradicted 1 contradicted online 3 overstated 3 needing context 25 supported 7 unverified
7 No source found (not proven false)
NHANES data show that many people in the US consume inadequate levels of essential micronutrients like folate, vitamin K, and selenium despite consuming excess calories.
"according to a lot of these NHANES studies coming out, getting inadequate levels of many of these micronutrients. You'd think if you're overnourishing yourself that you then would have adequate levels of micronutrients, but the thing is people are eating the wrong food. They're eating the wrong foods, and so they're not getting all their folate, vitamin K, selenium; they're not getting all these important micronutrients." (said at 0:16:25)
No published record matching the claim that NHANES data show widespread inadequate levels of folate, vitamin K, and selenium despite excess calorie intake was located; this does not prove the claim false.
The respiratory quotient (RQ) for ethanol metabolism is approximately 0.67, for carbohydrates is 1.0, for fats is 0.69 to 0.70, and for amino acids averages 0.84.
"you'll see that, you know, you get a two on one side, three on the other, and you do the two and then three, and you get the respiratory quotient of 0.67... Carbohydrates of all types, doesn't matter what kind they are, all of the glucose, anything that's dropping in there, those have a respiratory quotient about 1. And then fats or lipids all run between 0.69 and 0.7. So what's really interesting is that amino acids, they average 0.84 if I average all of them." (said at 0:27:50)
No published record matching the claim regarding the specific respiratory quotient values for ethanol (0.67), carbohydrates (1.0), fats (0.69–0.70), and amino acids (averaging 0.84) was located; this does not prove the claim false.
Eating food generates NADH, which directly shuts off SIRT1 activation.
"And SIRT1 gets activated every time you're making—so when you're eating anything, you know, when you're eating food you're going to make NADH, which shuts off SIRT1" (said at 0:51:59)
No published record matching the claim that eating food generates NADH which directly shuts off SIRT1 activation was located; this does not prove the claim false.
Cold exposure below 62 to 63 degrees Fahrenheit (17 degrees Celsius) increases norepinephrine levels.
"based on the fact that cold, if you're if you're—I think it's around 60, anything below 62 or 63 degrees Fahrenheit, 17 degrees Celsius, so yeah, it increases norepinephrine." (said at 1:21:16)
No published record matching the claim that cold exposure specifically below 62 to 63 degrees Fahrenheit (17 degrees Celsius) serves as a discrete threshold to increase norepinephrine levels was located; this does not prove the claim false.
Mild cold stress begins at 80 degrees Fahrenheit in water and 60 degrees Fahrenheit in air, which is where metabolic and hormonal responses start to occur.
"mild cold stress begins at 80 F in water, okay? And it's uh it begins at 60 F in air. So that's about where the that's where you start seeing a change. You start seeing a metabolic response, you start seeing a hormonal hormonal response um at about those temperatures." (said at 1:22:00)
No published record matching the specific thresholds of 80°F in water and 60°F in air as the starting points for mild cold stress, metabolic changes, and hormonal responses was located; this does not prove the claim false.
In a cold immersion test with journalist Steven Leckart in 70-degree Fahrenheit water, his respiratory quotient shifted from 1.0 (glycogen burning) to nearly 0.7 (predominantly fat burning), and fat oxidation remained elevated for over an hour after exiting the water.
"And his respiratory quotient went from 1.0, which is most activities are burning glycogen, almost to 0.7, almost pure fat. And for over an hour, he was still burning fat." (said at 1:28:20)
No published record matching the claim of a cold immersion test in journalist Steven Leckart showing a respiratory quotient shift from 1.0 to 0.7 and sustained fat oxidation for over an hour post-exposure was located; this does not prove the claim false.
Melatonin regulates approximately 500 different human genes, representing roughly 2.5% of the human genome.
"HOST: Melatonin is a hormone, regulates 500 different genes. GUEST1: Yeah, I mean that's 2.5% of the human genome." (said at 1:52:42)
No published record matching the claim that melatonin specifically regulates approximately 500 human genes (or roughly 2.5% of the human genome) was located; this does not prove the claim false. While melatonin is well established to influence gene expression across various physiological pathways and circadian networks, specific genomic profiling attributing regulation of a discrete set of 500 genes or exactly 2.5% of the human genome to melatonin has not been documented in peer-reviewed literature.
Unverified means no publication matching the claim was located; it does not prove the claim false. Spotted an error? See the corrections policy - disputes from the people quoted are prioritized.