14 Supported by research
Standing on vibration plates is beneficial for countering osteoporosis.
"There's also data that shows that standing on the vibration plates are very beneficial to counter osteoporosis." (said at 0:11:20)
Multiple systematic reviews and meta-analyses of randomized controlled trials demonstrate that whole-body vibration (WBV) therapy using vibration platforms has beneficial effects on bone mineral density (BMD), particularly at the lumbar spine and femoral neck, in postmenopausal women with osteopenia or osteoporosis. While the magnitude of improvement in BMD is generally modest and dependent on specific frequency, amplitude, and cumulative exposure parameters, published clinical trial data supports the claim that vibration plate training provides therapeutic benefit for countering osteoporosis.
- supports: Systematic review and meta-analyses on the effects of whole-body vibration on bone health. (Complementary therapies in medicine 2022) · cited 20x in the literature
"Meta-analysis of 30 studies revealed bone density improvement after whole body vibration (Hedges' g = 0.11; p = 0.05; 95% CI = 0.00, 0.22)... Whole body vibration may be clinically useful as non-pharmacological/adjunct therapy to mitigate osteoporosis risk in healthy postmenopausal females." (abstract, results and conclusions)
pubmedfull study (doi) - supports: Effectiveness of whole-body vibration on bone mineral density in postmenopausal women: a s… (Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2023) · cited 43x in the literature
"At this time, considering the high quality of evidence, it is possible to recommend WBV using high frequency (≈ 30 Hz), low magnitude (≈ 0.3 g), and high cumulative dose (≈ 7000 min) to improve lumbar spine aBMD in postmenopausal women." (abstract, conclusions, passage verified)
pubmedfull study (doi) - supports: Therapeutic effects of whole-body vibration on postmenopausal women with osteoporosis: a s… (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2024) · cited 4x in the literature
"The meta-analysis results showed that WBV can significantly increase lumbar spine BMD (WMD=0.018; 95%CI: 0.004 to 0.032; P=0.011), femoral neck BMD (WMD=0.005, 95%CI: 0.001 to 0.011, P=0.0493), and reduce pain degree (WMD=-0.786; 95%CI: -1.300 to -0.272; P=0.0027) in PMOP... To conclude, WBV showed the potential to provide positive benefits in improving BMD and relieving pain of PMOP." (abstract, results and conclusions, passage verified)
pubmedfull study (doi)
TUDCA crosses the blood-brain barrier.
"It can actually go systemically through the entire body, across the blood-brain barrier, go into your eyes." (said at 0:20:51)
Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid conjugate that is widely documented to be orally bioavailable and capable of crossing the blood-brain barrier (BBB) via passive diffusion and bile acid transporters, reaching the central nervous system to exert neuroprotective and anti-apoptotic effects in various neurological models.
- supports: Bile Acids Reduce Prion Conversion, Reduce Neuronal Loss, and Prolong Male Survival in Mod… (Journal of virology 2015) · cited 61x in the literature
"Our findings, together with the fact that these natural compounds are orally bioavailable, permeable to the blood-brain barrier, and U.S. Food and Drug Administration-approved for use in humans, make these compounds promising alternatives for the treatment of prion diseases." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Roles of bile acids signaling in neuromodulation under physiological and pathological cond… (Cell & bioscience 2023) · cited 115x in the literature
"Circulating BA could cross the blood brain barrier (BBB) and reach the CNS through passive diffusion or BA transporters." (abstract, results, passage verified)
pubmedfull study (doi) - supports: The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the re… (Metabolic brain disease 2025) · cited 13x in the literature
"UDCA and its taurine conjugate (TUDCA), which are endogenous bile acids, have exhibited neuroprotective potential in various neurological conditions, such as Alzheimer's disease, Parkinson's disease and Huntington's disease, in both animal experimental models and clinical investigations. This is attributed to three significant properties, in addition to their capability to cross the blood-brain barrier." (abstract, results, passage verified)
pubmedfull study (doi)
B vitamin deficiency can cause cracked lips.
"Even B vitamin deficiency can create cracked lips." (said at 0:30:17)
Deficiencies in several B-complex vitamins—particularly riboflavin (vitamin B2), as well as pyridoxine (vitamin B6), folate (vitamin B9), and cobalamin (vitamin B12)—are well-established causes of cheilosis and angular stomatitis/cheilitis (fissuring, inflammation, and cracking of the lips and mouth corners).
- supports: Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms. (Cutaneous and ocular toxicology 2014) · cited 47x in the literature
"Hyperpigmentation was reported in 49 (85.96%) patients enrolled in the study; atrophic glossitis in 40 (70.17%), brittle and matt hair in 13 (22.80%), skin lesions (particularly diaper dermatitis) in eight (15.78%) and cheilosis in four (7.01%) patients." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Causes and Clinical Sequelae of Riboflavin Deficiency. (Annual review of nutrition 2023) · cited 68x in the literature
"Severe riboflavin deficiency, largely confined to low-income countries, clinically manifests as cheilosis, angular stomatitis, glossitis, seborrheic dermatitis, and severe anemia with erythroid hypoplasia." (abstract, results, passage verified)
pubmedfull study (doi)
Scientific data does not support the idea that dietary acid or alkaline intake can dramatically alter systemic blood pH due to buffering mechanisms.
"there's no real data that shows that you can dramatically alter your pH by just I'm just now going to start eating more acids because the body is constantly buffering and things like that." (said at 0:30:49)
The host's statement that scientific data does not support dramatic alterations in systemic blood pH via dietary acid or alkaline intake due to homeostatic buffering mechanisms is supported by clinical research. Systemic acid-base homeostasis is tightly regulated by physiological buffering systems, renal excretion, and respiratory compensation. Clinical trials investigating protein-rich or acid-base dietary interventions show that while acidifying or alkalizing diets or supplements may induce minor fluctuations in urinary pH, blood bicarbonate concentrations, or tissue-level markers, they fail to induce substantial or dramatic shifts in systemic blood pH (Fenton et al., 2011, PMID 21529374; Ströhle et al., 2020, PMID 32873957). Randomized trials confirm that standard dietary acid loads do not significantly alter baseline acid-base homeostasis or systemic blood pH in healthy adults.
Butterbur herb is supported by solid research as an effective remedy for migraine headaches.
"There's also, just as a side note, a wonderful herb that I stumbled on that has hardcore research on migraines. It's called butterbur um herb. Check it out if you have migraines. It might be something that can help." (said at 0:40:35)
Multiple randomized, double-blind, placebo-controlled clinical trials and systematic reviews demonstrate that standardized butterbur root extract (Petasites hybridus, specifically 75 mg twice daily / 150 mg daily) is effective in reducing the frequency of migraine attacks compared to placebo. Clinical guidelines, such as the Canadian Headache Society migraine prophylaxis guideline, have formally recommended butterbur for migraine prevention based on randomized trial evidence.
- supports: Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. (Neurology 2004) · cited 256x in the literature
"Over 4 months of treatment, in the per-protocol analysis, migraine attack frequency was reduced by 48% for Petasites extract 75 mg bid (p = 0.0012 vs placebo), 36% for Petasites extract 50 mg bid (p = 0.127 vs placebo), and 26% for the placebo group." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systema… (Phytomedicine : international journal of phytotherapy and phytopharmacology 2006) · cited 54x in the literature
"The extract at higher dose (150 mg) showed a greater decreased frequency of migraine attacks and a greater number of responders (improvement>50%) after treatment over 3-4 months than the extract at lower dose (100 mg) and placebo. Moderate evidence of effectiveness is, thus, available for a higher than the recommended dose of the proprietary Petasites root extract Petadolex in the prophylaxis of migraine." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Canadian Headache Society guideline for migraine prophylaxis. (The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2012) · cited 272x in the literature
"Based on our review, 11 prophylactic drugs received a strong recommendation for use (topiramate, propranolol, nadolol, metoprolol, amitriptyline, gabapentin, candesartan, butterbur, riboflavin, coenzyme Q10, and magnesium citrate) and 6 received a weak recommendation..." (abstract, results, passage verified)
pubmed
Nitric oxide facilitates arterial vasodilation, decreases with aging, and is significantly depleted by high glucose levels in the bloodstream.
"What allows the arteries to be very very u vasodilated and relaxed is uh nitric oxide. Nitric oxide as we age it does go down but the biggest killer of that is too much glucose flowing through that those blood vessels. It'll just wipe out the nitric oxide." (said at 0:42:00)
Nitric oxide (NO) is the primary endothelium-derived relaxing factor responsible for vascular smooth muscle relaxation and arterial vasodilation. Established clinical and mechanistic literature demonstrates that NO bioavailability declines progressively with aging and is markedly impaired by hyperglycemia. High blood glucose levels promote reactive oxygen species (ROS) production, endothelial nitric oxide synthase (eNOS) uncoupling, and advanced glycation end-products, all of which directly quench NO and diminish endothelial vasodilation.
- supports: Vascular endothelial dysfunction and pharmacological treatment. (World journal of cardiology 2015) · cited 238x in the literature
"Different risk factors such as hypercholesterolemia, homocystinemia, hyperglycemia, hypertension, smoking, inflammation, and aging contribute to the development of endothelial dysfunction... Among these mechanisms, a reduction in nitric oxide (NO) bioavailability plays a central role in the development of endothelial dysfunction because NO exerts diverse physiological actions, including vasodilation, anti-inflammation, antiplatelet, antiproliferation and antimigration." (abstract, results)
pubmedfull study (doi) - supports: Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel… (Biochemical pharmacology 2022) · cited 83x in the literature
"Endothelial dysfunction is a systemic disorder in which traditional cardiovascular risk factors, such as aging, gender, hypertension, smoking, hyperglycemia, and dyslipidemia... act synergistically to tip the endothelial balance in favor of vasoconstrictive, pro-inflammatory, and pro-thrombotic phenotypes... The hallmark of endothelial dysfunction is a marked reduction of nitric oxide (NO) bioavailability owing to epigenetic-sensitive dysregulation of the endothelial nitric oxide synthase (eNOS) gene and upregulation of reactive oxygen species (ROS) in endothelial cells (ECs)." (abstract, results)
pubmedfull study (doi)
Oral bacteria produce nitric oxide precursors, and mouthwash kills the oral microbes responsible for nitric oxide production.
"your microbes do make it. And this is why like mouthwash really kills off the microbes that help you make nitric oxide" (said at 0:42:35)
The host's statement that oral bacteria help generate nitric oxide (via the enterosalivary nitrate-nitrite-nitric oxide pathway) and that antibacterial mouthwashes disrupt these microbes is supported by extensive human clinical literature. Human salivary bacteria (such as *Veillonella*, *Actinomyces*, and *Rothia*) express nitrate reductases that reduce dietary nitrate to nitrite, which is subsequently converted into nitric oxide systemically. Randomized controlled trials demonstrate that broad-spectrum antibacterial mouthwashes (such as chlorhexidine) significantly reduce nitrate-reducing oral bacteria, lower salivary and plasma nitrite levels, and blunts nitric oxide generation.
Statin medications block and deplete coenzyme Q10 in the body.
"They're pretty smart because it is co-enzyme Q10. It blocks co-enzyme Q10. So, um, this is why if someone is on a statin, they better be taking co-enzyme Q10." (said at 0:49:23)
Statin medications inhibit HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway. Because mevalonate is a common precursor for both cholesterol and ubiquinone (coenzyme Q10) synthesis, statin treatment blocks endogenous CoQ10 biosynthesis and significantly lowers circulating and cellular CoQ10 concentrations in humans and animal models.
In the human circadian rhythm, cortisol levels are naturally at their lowest around 2:00 AM and peak at 8:00 AM.
"You want it at the very lowest at 2:00 in the middle of the night, 2:00 a.m. Okay. And it should be the highest at 8:00 a.m." (said at 0:50:54)
The speaker's description of human circadian cortisol timing is supported by established endocrinology research. In healthy individuals on a typical diurnal sleep-wake schedule, cortisol secretion follows a robust 24-hour circadian rhythm governed by the hypothalamic-pituitary-adrenal (HPA) axis. Systemic cortisol levels reach their lowest point (nadir) around the middle of the night (typically midnight to 2:00 AM) and peak in the early morning shortly after awakening (around 7:00 to 9:00 AM).
The final stage of converting vitamin D into its active form requires functioning kidneys.
"that last stage of conversion of vitamin D to the active form requires a good kidney" (said at 0:46:47)
The synthesis of biologically active vitamin D is a multi-step process. Vitamin D precursors undergo initial 25-hydroxylation in the liver to form 25-hydroxyvitamin D (calcifediol). The final activation step to form 1,25-dihydroxyvitamin D (calcitriol) occurs primarily in the proximal tubules of the kidneys via the 1-alpha-hydroxylase enzyme (encoded by CYP27B1). Consequently, functional renal tissue is required to maintain adequate physiological conversion and circulating levels of active vitamin D.
- supports: Regulation of 1 and 24 hydroxylation of vitamin D metabolites in the proximal tubule. (Experimental biology and medicine (Maywood, N.J.) 2022) · cited 44x in the literature
"Calcitriol synthesis is a multistep process. A precursor is first made via skin exposure to UV, it is then 25-hydroxylated in the liver to form 25-hydroxyitamin D. The next hydroxylation step occurs in the renal proximal tubule via the 1-αhydroxylase enzyme (encoded by CYP27B1) thereby generating 1,25-dihydroxyvitamin D, that is, calcitriol." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress. (Nutrients 2023) · cited 129x in the literature
"In addition, 25(OH)D can be primarily converted into calcitriol (1,25-dihydroxycholecalciferol [1,25(OH)2D]) in the kidneys through the action of the 1-α-hydroxylase enzyme." (abstract, results, passage verified)
pubmedfull study (doi)
Increasing dietary potassium intake has been shown to reduce the risk of stroke.
"taking more potassium has been shown to reduce reduce excuse me the risk of a stroke and a 100% of respondents say that's true. HOST: That's some confidence right there. Yes, potassium is fascinating." (said at 0:54:01)
Multiple systematic reviews and meta-analyses of prospective cohort studies demonstrate that higher dietary potassium intake is significantly associated with a reduced risk of stroke. A meta-analysis published in the BMJ found that higher potassium intake was associated with a 24% reduction in incident stroke risk (RR 0.76, 95% CI 0.66–0.89), alongside randomized trial evidence showing that increased potassium lowers blood pressure in adults with hypertension. Another dose-response meta-analysis in the Journal of the American Heart Association confirmed a 13% lower stroke risk comparing highest to lowest potassium intake categories (RR 0.87, 95% CI 0.80–0.94), with maximum risk reduction observed at around 3,500 mg (90 mmol) of daily potassium intake.
- supports: Potassium intake, stroke, and cardiovascular disease a meta-analysis of prospective studie… (Journal of the American College of Cardiology 2011)
"In the pooled analysis, a 1.64-g (42 mmol) per day higher potassium intake was associated with a 21% lower risk of stroke (RR: 0.79; 95% CI: 0.68 to 0.90; p = 0.0007)" (abstract, results, passage verified)
pubmedfull study (doi) - supports: Effect of increased potassium intake on cardiovascular risk factors and disease: systemati… (BMJ (Clinical research ed.) 2013) · cited 968x in the literature
"An inverse statistically significant association was seen between potassium intake and risk of incident stroke (risk ratio 0.76, 0.66 to 0.89). ... Higher potassium intake was associated with a 24% lower risk of stroke (moderate quality evidence)." (abstract, results and conclusions)
pubmedfull study (doi) - supports: Meta-Analysis of Potassium Intake and the Risk of Stroke. (Journal of the American Heart Association 2016) · cited 129x in the literature
"Relative to the lowest category of potassium intake, the highest category of potassium intake was associated with a 13% reduced risk of stroke (RR=0.87, 95% CI 0.80-0.94) in the blood pressure-adjusted analysis. ... Overall, this dose-response meta-analysis confirms the inverse association between potassium intake and stroke risk, with potassium intake of 90 mmol (≈3500 mg)/day associated with the lowest risk of stroke." (abstract, results and conclusions, passage verified)
pubmedfull study (doi)
UVB phototherapy has been demonstrated to effectively treat and clear psoriasis.
"there's also another uh valid therapy using UVB uh lights and that's been shown to dramatically get rid of psoriasis." (said at 0:59:10)
Ultraviolet B (UVB) phototherapy, particularly narrowband UVB (NB-UVB), is an established first-line phototherapeutic treatment that effectively treats and clears chronic plaque and guttate psoriasis. Systematic reviews of randomized controlled trials demonstrate high response rates, with approximately 70% of patients achieving at least a 75% reduction in Psoriasis Area and Severity Index (PASI 75) score and substantial disease clearance in both outpatient clinic and home settings.
Modern cultivated fruits such as Honeycrisp apples, pineapples, pears, and peaches have been hybridized and bred to have significantly higher sugar and fructose content than ancestral or indigenous varieties.
"they've been hybridized to be super high in sugar. Uh especially like pineapple and um uh even some of these uh honeycrisp apples like versus you know apples used to be more like indigenous kind of sour and not that sweet. Even like indigenous uh pears are like not that sweet and even peaches are certain are not that sweet but they've been bred for more sugar which gives you more fructose." (said at 1:00:43)
Human domestication and selective breeding of fruit crops (such as apples, pears, and peaches) have systematically increased fruit sweetness and sugar content (specifically simple sugars like fructose and sucrose) compared to wild or ancestral ancestors. Population genomics studies confirm that artificial selection during domestication and modern improvement directly targeted fruit taste and sugar accumulation pathways—for instance, selecting for increased fructose content in modern peach cultivars via transport genes such as PpERDL16 and sweet/acid balance loci across wild vs. cultivated fruit species.
- supports: Diversification and independent domestication of Asian and European pears (Genome biology 2018) · cited 318x in the literature
"In addition, separate selective sweep signatures between Asian pears and European pears, combined with co-localized QTLs and differentially expressed genes, underline distinct phenotypic fruit traits, including flesh texture, sugar, acidity, aroma, and stone cells." (abstract, results, passage verified)
openalexfull study (doi) - supports: Genomic analyses of an extensive collection of wild and cultivated accessions provide new … (Genome biology 2019) · cited 226x in the literature
"In contrast, fruit taste-related QTLs were successively selected for by domestication and improvement, with more QTLs selected for during improvement." (abstract, results, passage verified)
openalexfull study (doi) - supports: Population-scale peach genome analyses unravel selection patterns and biochemical basis un… (Nature Communications 2021) · cited 83x in the literature
"Population genomic analyses reveal a fascinating history of convergent selection for sweetness yet divergent selection for acidity in eastern vs. western modern cultivars. Molecular-genetics and biochemical analyses establish that PpALMT1 (aluminum-activated malate transporter 1) contributes to their difference of malate content and that increases fructose content accounts for the increased sweetness of modern peach fruits, as regulated by PpERDL16 (early response to dehydration 6-like 16)." (abstract, results, passage verified)
openalexfull study (doi)
Tinnitus or ringing in the ears frequently results from prior exposure to loud sounds or explosions that caused ear damage.
"A lot of times um ringing in the ear has occurred um from old loud sounds or explosions that could have damaged the ear that now it's showing up." (said at 1:02:20)
The speaker's claim that tinnitus frequently develops from past exposure to loud noises or explosions causing ear damage is supported by clinical and epidemiological research. Large cohort studies and systematic reviews demonstrate that acoustic trauma, occupational or combat noise exposure, and blast injuries are major risk factors for tinnitus. For example, analysis of over 750,000 military veterans in the Million Veteran Program showed that daily combat noise exposure and traumatic injuries significantly increased the risk of tinnitus compared to age alone, with tinnitus frequently presenting as a long-term consequence of prior acoustic injury.
- supports: Auditory changes following firearm noise exposure, a review. (The Journal of the Acoustical Society of America 2022) · cited 14x in the literature
"Noise-induced tinnitus and hearing loss are common in military service members, public safety officers, and hunters/shooters." (abstract, results, passage verified)
pubmedfull study (doi) - supports: The Interrelationship of Tinnitus and Hearing Loss Secondary to Age, Noise Exposure, and T… (Ear and hearing 2022) · cited 16x in the literature
"A multivariate model indicated a higher RR of 1.73 for traumatic brain injury (95% CI, 1.71 to 1.73) and daily combat noise exposure (1.17, 95% CI, 1.14 to 1.17) than age (0.998, 95% CI, 0.997 to 0.998)." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Blast Exposure Associations With Hearing Loss and Self-Reported Hearing Difficulty. (Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2024) · cited 4x in the literature
"Results suggest that blast exposure is a prevalent source of hearing injury in the military." (abstract, results, passage verified)
pubmedfull study (doi)
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