Andrew Koutnik
Andrew Koutnik is a researcher in the fields of nutrition, exercise physiology, and metabolism. His published research focuses on the effects of carbohydrate intake, exogenous ketone supplementation, and ketogenic diets on exercise performance, metabolism, and cognitive function. Additionally, his work investigates the physiological and cardiovascular impacts of nutritional interventions in individuals with type 1 diabetes.
42 claims checked on air: 5 context 1 contradicted 2 overstated 25 supported 9 unverified
What they said on air - unverified
4 citing their own research
Ninety-nine percent of patients diagnosed with type 1 diabetes never achieve normal metabolic control after diagnosis.
"where 99% of patients will never get normal metabolic control after their initial diagnosis." (said at 0:15:40)
No published record matching the claim that 99% of patients diagnosed with type 1 diabetes never achieve normal metabolic control after diagnosis was located; this does not prove the claim false.
William Sansum was the first person in the United States to chemically extract and administer insulin to save a patient's life.
"So, William Sansum, where I used to work, was actually the first person in the United States of America to both chemically extract and also administer insulin to save the life of a patient in the United States of America." (said at 0:28:40)
No published record matching the claim that William Sansum was the first person in the United States to chemically extract and administer insulin to save a patient's life was located; this does not prove the claim false.
In 1925, William Sansum published a paper in JAMA advocating that patients receiving insulin should have enhanced dietary freedom, without support from randomized controlled trials.
"William Sansum the founder of the institute I worked at also published a paper in JAMA in 1925 where he then argued that patients with the ability to administer insulin should now have enhanced freedom in their dietary choices. He made this recommendation in the absence of any serious, rigorous, randomized control trial evidence." (said at 0:29:00)
No published record matching William Sansum's 1925 JAMA paper on enhanced dietary freedom for insulin-treated patients was located; this does not prove the claim false.
The American Diabetes Association issued its first nutritional guidance in the 1970s, modeling it on the inaugural U.S. Dietary Guidelines.
"And the American Diabetes Association in 1970s for the first time came out with their first nutritional guidance. And essentially what they did is they modeled the US dietary guidelines that first came out in the 1970s." (said at 0:29:40)
No published record matching the claim that the American Diabetes Association issued its first nutritional guidance in the 1970s modeled on the inaugural U.S. Dietary Guidelines was located; this does not prove the claim false.
There are four times more published studies on pharmacological and technological diabetes advancements than on nutrition-based diabetes interventions.
"And they're fourfold higher more publications in just pharmacological and technological advancements than there is in nutrition." (said at 0:30:10)
No published record matching the claim that there are four times (or fourfold) more publications on pharmacological and technological diabetes advancements than on nutrition-based diabetes interventions was located; this does not prove the claim false.
In 1962, MIT studied 1,3-butanediol for aerospace transport as a shelf-stable, high-caloric-density nutrient.
"So, then in 1962, MIT actually studied 1,3-butanediol, which is in products like Ketone-IQ, for aerospace transport. Why were they interested in that? Because it was a very shelf-stable molecule that could go into outer space with high caloric density." (said at 0:50:20)
No published record matching the claim that MIT studied 1,3-butanediol in 1962 as a shelf-stable, high-caloric-density nutrient for aerospace transport was located; this does not prove the claim false.
High-intensity athletic performance (6x800m sprints and 1-mile time trials above 85% VO2 max) did not deteriorate after 4 or more weeks on a ketogenic diet compared to a high-carbohydrate diet.
"what we found is that when athletes were either on a ketogenic diet or on a high-carb diet doing 6 by 800-meter sprints or a max-effort 1-mile time trial—so the fastest you can run for 4 to 6 minutes in duration—we found that the ketogenic diet did not produce any deterioration in physical performance in these high-intensity athletic endeavors." (said at 0:58:45)
No published record matching the specific study described (evaluating 6x800m sprints and a 1-mile time trial following 4 or more weeks of a ketogenic diet versus a high-carbohydrate diet) was located; this does not prove the claim false. Published randomized trials by the speaker and colleagues have evaluated acute meal-timing effects on 5k and 10k running, but peer-reviewed findings for this specific multi-week sprint and 1-mile interval intervention protocol have not appeared in the indexed literature.
Total circulating brain energy metabolites in the blood—including glucose, ketones, and lactate—are equivalent between high-carbohydrate adapted and ketogenic adapted endurance athletes.
"in the blood, not just glucose, but also ketones and lactate, all fuels for the brain, the high carbohydrate athletes and the ketogenic athletes had the same amount of brain energy metabolites circulating in the blood." (said at 1:03:03)
No published record matching the claim that total circulating brain energy metabolites (glucose, ketones, and lactate combined) are equivalent between high-carbohydrate adapted and ketogenic adapted endurance athletes was located; this does not prove the claim false.
In a review of over 160 sports nutrition studies published in Endocrine Reviews, when carbohydrate feeding reliably improved performance, the placebo/control group experienced a precipitous drop in blood glucose levels 88% of the time.
"And what we found is that when we looked at these 160 different studies, when carbohydrates reliably improved performance, David, what was happening is that the placebo group of those studies, 88% of the time, the placebo or control group was seeing a precipitous drop in blood glucose levels." (said at 1:06:45)
No published record matching a review of over 160 sports nutrition studies in Endocrine Reviews reporting that placebo/control groups experienced a precipitous drop in blood glucose levels 88% of the time when carbohydrate feeding improved performance was located; this does not prove the claim false.
Fact-checked episodes
Publications
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.Endocrine reviews 2026 · CEBM Level 5
- The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial.Journal of the American Nutrition Association 2026 · CEBM Level 2
- Effect of Acute Ingestion of a Ketone Monoester on Psychomotor Vigilance During Acute Severe Hypoxia Exposure.Military medicine 2026 · CEBM Level 2
- Carbohydrate ingestion eliminates hypoglycemia and improves endurance exercise performance in triathletes adapted to very low- and high-carbohydrate isocaloric diets.American journal of physiology. Cell physiology 2025 · CEBM Level 2
- Multisystem impact of altering acid load of ingested exogenous ketone supplements at rest in young healthy adults.American journal of physiology. Regulatory, integrative and comparative physiology 2025 · CEBM Level 2
- Substrate Oxidation Does Not Influence Middle Distance Running Performance: A Randomized Controlled Crossover Trial.Nutrients 2025 · CEBM Level 2
- Coronary artery calcification in type 1 diabetes after 10-year ketogenic diet.Journal of applied physiology (Bethesda, Md. : 1985) 2025 · CEBM Level 4
- A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection.European journal of human genetics : EJHG 2024 · CEBM Level 5
- A Ketone Monoester with Carbohydrate Improves Cognitive Measures Postexercise, but Not Performance in Trained Females.Medicine and science in sports and exercise 2024 · CEBM Level 2
- Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance.Frontiers in nutrition 2024 · CEBM Level 5
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology 2024 · CEBM Level 4
- The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet.Nutrients 2024 · CEBM Level 5
- Efficacy and Safety of Long-term Ketogenic Diet Therapy in a Patient With Type 1 Diabetes.JCEM case reports 2024 · CEBM Level 4
- Differential Rates of Glycation Following Exposure to Unique Monosaccharides.International journal of molecular sciences 2024 · CEBM Level 5
- Ketone monoester attenuates oxygen desaturation during weighted ruck exercise under acute hypoxic exposure but does not impact cognitive performance.Experimental physiology 2024 · CEBM Level 2
- Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions.Experimental physiology 2024 · CEBM Level 2
- Low and high carbohydrate isocaloric diets on performance, fat oxidation, glucose and cardiometabolic health in middle age males.Frontiers in nutrition 2023 · CEBM Level 2
- Metabolic and ruck performance effects of a novel, light-weight, energy-dense ketogenic bar.Experimental physiology 2023 · CEBM Level 2
- A Glutamate Scavenging Protocol Combined with Deanna Protocol in SOD1-G93A Mouse Model of ALS.Nutrients 2023 · CEBM Level 5
- Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future.Sports medicine (Auckland, N.Z.) 2022 · CEBM Level 5
- Resting-state heart rate variability after stressful events as a measure of stress tolerance among elite performers.Frontiers in physiology 2022 · CEBM Level 4
- From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience.GeroScience 2021 · CEBM Level 5
- Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom.The Journal of clinical investigation 2021 · CEBM Level 5
- Ketone Bodies Impact on Hypoxic CO 2 Retention Protocol During Exercise.Frontiers in physiology 2021 · CEBM Level 2
- Ketone Bodies Attenuate Wasting in Models of Atrophy.Journal of cachexia, sarcopenia and muscle 2020 · CEBM Level 5
- Effects of an Exogenous Ketone Supplement on Five-Kilometer Running Performance.Journal of human kinetics 2020 · CEBM Level 2
- Exogenous Dietary Ketone Ester Decreases Body Weight and Adiposity in Mice Housed at Thermoneutrality.Obesity (Silver Spring, Md.) 2020 · CEBM Level 5
- Nutritional Ketosis with Ketogenic Diets or Exogenous Ketones: Features, Convergence, and Divergence.Current sports medicine reports 2020 · CEBM Level 5
- Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models.Nutrients 2020 · CEBM Level 5
- Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.Med (New York, N.Y.) 2020 · CEBM Level 5
- Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters.Nutrition & metabolism 2020 · CEBM Level 2
- Human Adaptations to Multiday Saturation on NASA NEEMO.Frontiers in physiology 2020 · CEBM Level 4
- Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.Seminars in cancer biology 2019 · CEBM Level 5
- Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements.Physiological reports 2019 · CEBM Level 5
- Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.Trends in endocrinology and metabolism: TEM 2019 · CEBM Level 5
- Concentration-Dependent Effects of a Dietary Ketone Ester on Components of Energy Balance in Mice.Frontiers in nutrition 2019 · CEBM Level 5
- Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models.Nutrients 2019 · CEBM Level 5
- Commentary: Ketone Diester Ingestion Impairs Time-Trial Performance in Professional Cyclists.Frontiers in physiology 2018 · CEBM Level 5
- Stair climbing exercise as a novel health intervention for menopause: cardiovascular and skeletal muscle implications.Menopause (New York, N.Y.) 2018 · CEBM Level 5
- Nutritional ketosis delays the onset of isoflurane induced anesthesia.BMC anesthesiology 2018 · CEBM Level 5
- Corrigendum: Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.Frontiers in molecular neuroscience 2017 · CEBM Level 5
- Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 · CEBM Level 5
- Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.PloS one 2017 · CEBM Level 5
- Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.Frontiers in molecular neuroscience 2016 · CEBM Level 5
- Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation.Psychophysiology 2015 · CEBM Level 4
- Acute passive vibration reduces arterial stiffness and aortic wave reflection in stroke survivors.European journal of applied physiology 2014 · CEBM Level 2
- School burnout and cardiovascular functioning in young adult males: a hemodynamic perspective.Stress (Amsterdam, Netherlands) 2014 · CEBM Level 4
- Impact of acute whole-body cold exposure with concurrent isometric handgrip exercise on aortic pressure waveform characteristics.European journal of applied physiology 2014 · CEBM Level 2
- Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy.The Journal of biological chemistry 2014 · CEBM Level 5
- Depressive symptoms contribute to increased wave reflection during cold pressor test in young adult men.American journal of hypertension 2013 · CEBM Level 4
- The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise.American journal of hypertension 2013 · CEBM Level 2
- Sympathetic vasomotor tone is associated with depressive symptoms in young females: a potential link between depression and cardiovascular disease.American journal of hypertension 2013 · CEBM Level 4