Andrew Koutnik
Andrew Koutnik is a researcher in the fields of nutrition, exercise physiology, and metabolism. His published research focuses on the effects of carbohydrate intake, exogenous ketone supplementation, and ketogenic diets on exercise performance, metabolism, and cognitive function. Additionally, his work investigates the physiological and cardiovascular impacts of nutritional interventions in individuals with type 1 diabetes.
42 claims checked on air: 5 context 1 contradicted 2 overstated 25 supported 9 unverified
What they said on air - contradicted
4 citing their own research
Consuming 120 grams of carbohydrates per hour during prolonged strenuous exercise suppresses fat metabolism to approximately 10% of total energy expenditure and shifts over 85% of fuel utilization to glucose, primarily from muscle glycogen.
"when they compare 120 g of carbohydrates per hour compared to just 25 g per hour, one at 120 g per hour, insulin was infinitely higher, okay? But you essentially blocked fat metabolism to around 10% of total energy substrate used during a prolonged strenuous form of exercise. And you expedited muscle glycogen breakdown. Over 85% of the fuel came from glucose and most of it from muscle glycogen." (said at 1:08:19)
The claim asserts that ingesting 120 g/h of carbohydrates during prolonged strenuous exercise "expedited muscle glycogen breakdown" and that "most of it [came] from muscle glycogen." In exercise physiology and tracer studies, exogenous carbohydrate ingestion does not expedite (accelerate) muscle glycogen breakdown; rather, exogenous carbohydrate increases exogenous carbohydrate oxidation and either spares endogenous glycogen stores (particularly liver glycogen and muscle glycogen) or leaves endogenous carbohydrate oxidation unchanged compared to lower doses. Isotope tracer studies evaluating 90–120 g/h carbohydrate ingestion demonstrate that high exogenous carbohydrate intake delivers substantial circulating fuel (exogenous oxidation reaching ~1.5–1.7 g/min), reducing reliance on endogenous stores rather than accelerating glycogen depletion.
- contradicts: Glucose and Fructose Hydrogel Enhances Running Performance, Exogenous Carbohydrate Oxidati… (Medicine and science in sports and exercise 2022) · cited 36x in the literature
"Absolute and relative endogenous CHO oxidation was lower in both CHO conditions compared with placebo (P < 0.001), with no difference between CHO conditions. Absolute and relative liver glucose oxidation and muscle glycogen oxidation were not different between CHO conditions." (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: Increased exogenous but unaltered endogenous carbohydrate oxidation with combined fructose… (European journal of applied physiology 2022) · cited 36x in the literature
"Exogenous carbohydrate oxidation rates were higher in the 120 g h -1 condition (120-180 min: 1.51 ± 0.22 g min -1 ) as compared to the 90 g h -1 condition (1.29 ± 0.16 g min -1 ; p = 0.026). Endogenous carbohydrate oxidation rates did not differ between conditions (2.15 ± 0.30 and 2.20 ± 0.33 g min -1 for 120 and 90 g h -1 conditions, respectively; p = 0.786)." (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: From Metabolism to Medals: Contemporary Perspectives and Revisiting Carbohydrate Guideline… (The Journal of nutrition 2026) · cited 4x in the literature
"From a metabolic perspective, the ergogenic effect of CHO intake is likely mediated by liver (and potentially muscle) glycogen sparing, maintenance of plasma glucose concentrations, and whole-body CHO oxidation rates, such that the required exercise intensity can be sustained for a longer duration thereby delaying fatigue." (abstract, results, passage verified)
pubmedfull study (doi)
Fact-checked episodes
Publications
- Carbohydrate Ingestion on Exercise Metabolism and Physical Performance.Endocrine reviews 2026 · CEBM Level 5
- The Effects of 31-Day Exogenous Ketone Consumption on Running Performance, Cognitive Function, Metabolism, Body Composition, Hemodynamics, and Mood in Recreational Runners: A Randomized-Control Trial.Journal of the American Nutrition Association 2026 · CEBM Level 2
- Effect of Acute Ingestion of a Ketone Monoester on Psychomotor Vigilance During Acute Severe Hypoxia Exposure.Military medicine 2026 · CEBM Level 2
- Carbohydrate ingestion eliminates hypoglycemia and improves endurance exercise performance in triathletes adapted to very low- and high-carbohydrate isocaloric diets.American journal of physiology. Cell physiology 2025 · CEBM Level 2
- Multisystem impact of altering acid load of ingested exogenous ketone supplements at rest in young healthy adults.American journal of physiology. Regulatory, integrative and comparative physiology 2025 · CEBM Level 2
- Substrate Oxidation Does Not Influence Middle Distance Running Performance: A Randomized Controlled Crossover Trial.Nutrients 2025 · CEBM Level 2
- Coronary artery calcification in type 1 diabetes after 10-year ketogenic diet.Journal of applied physiology (Bethesda, Md. : 1985) 2025 · CEBM Level 4
- A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: host extracellular to systemic effects of SARS-CoV-2 infection.European journal of human genetics : EJHG 2024 · CEBM Level 5
- A Ketone Monoester with Carbohydrate Improves Cognitive Measures Postexercise, but Not Performance in Trained Females.Medicine and science in sports and exercise 2024 · CEBM Level 2
- Expert consensus on nutrition and lower-carbohydrate diets: An evidence- and equity-based approach to dietary guidance.Frontiers in nutrition 2024 · CEBM Level 5
- Advanced cardiovascular physiology in an individual with type 1 diabetes after 10-year ketogenic diet.American journal of physiology. Cell physiology 2024 · CEBM Level 4
- The Metabolic and Endocrine Effects of a 12-Week Allulose-Rich Diet.Nutrients 2024 · CEBM Level 5
- Efficacy and Safety of Long-term Ketogenic Diet Therapy in a Patient With Type 1 Diabetes.JCEM case reports 2024 · CEBM Level 4
- Differential Rates of Glycation Following Exposure to Unique Monosaccharides.International journal of molecular sciences 2024 · CEBM Level 5
- Ketone monoester attenuates oxygen desaturation during weighted ruck exercise under acute hypoxic exposure but does not impact cognitive performance.Experimental physiology 2024 · CEBM Level 2
- Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions.Experimental physiology 2024 · CEBM Level 2
- Low and high carbohydrate isocaloric diets on performance, fat oxidation, glucose and cardiometabolic health in middle age males.Frontiers in nutrition 2023 · CEBM Level 2
- Metabolic and ruck performance effects of a novel, light-weight, energy-dense ketogenic bar.Experimental physiology 2023 · CEBM Level 2
- A Glutamate Scavenging Protocol Combined with Deanna Protocol in SOD1-G93A Mouse Model of ALS.Nutrients 2023 · CEBM Level 5
- Exogenous Ketone Supplements in Athletic Contexts: Past, Present, and Future.Sports medicine (Auckland, N.Z.) 2022 · CEBM Level 5
- Resting-state heart rate variability after stressful events as a measure of stress tolerance among elite performers.Frontiers in physiology 2022 · CEBM Level 4
- From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience.GeroScience 2021 · CEBM Level 5
- Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom.The Journal of clinical investigation 2021 · CEBM Level 5
- Ketone Bodies Impact on Hypoxic CO 2 Retention Protocol During Exercise.Frontiers in physiology 2021 · CEBM Level 2
- Ketone Bodies Attenuate Wasting in Models of Atrophy.Journal of cachexia, sarcopenia and muscle 2020 · CEBM Level 5
- Effects of an Exogenous Ketone Supplement on Five-Kilometer Running Performance.Journal of human kinetics 2020 · CEBM Level 2
- Exogenous Dietary Ketone Ester Decreases Body Weight and Adiposity in Mice Housed at Thermoneutrality.Obesity (Silver Spring, Md.) 2020 · CEBM Level 5
- Nutritional Ketosis with Ketogenic Diets or Exogenous Ketones: Features, Convergence, and Divergence.Current sports medicine reports 2020 · CEBM Level 5
- Exogenous Ketone Supplements Improved Motor Performance in Preclinical Rodent Models.Nutrients 2020 · CEBM Level 5
- Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections.Med (New York, N.Y.) 2020 · CEBM Level 5
- Dose response of a novel exogenous ketone supplement on physiological, perceptual and performance parameters.Nutrition & metabolism 2020 · CEBM Level 2
- Human Adaptations to Multiday Saturation on NASA NEEMO.Frontiers in physiology 2020 · CEBM Level 4
- Targeting the Warburg effect for cancer treatment: Ketogenic diets for management of glioma.Seminars in cancer biology 2019 · CEBM Level 5
- Delaying latency to hyperbaric oxygen-induced CNS oxygen toxicity seizures by combinations of exogenous ketone supplements.Physiological reports 2019 · CEBM Level 5
- Anticatabolic Effects of Ketone Bodies in Skeletal Muscle.Trends in endocrinology and metabolism: TEM 2019 · CEBM Level 5
- Concentration-Dependent Effects of a Dietary Ketone Ester on Components of Energy Balance in Mice.Frontiers in nutrition 2019 · CEBM Level 5
- Exogenous Ketones Lower Blood Glucose Level in Rested and Exercised Rodent Models.Nutrients 2019 · CEBM Level 5
- Commentary: Ketone Diester Ingestion Impairs Time-Trial Performance in Professional Cyclists.Frontiers in physiology 2018 · CEBM Level 5
- Stair climbing exercise as a novel health intervention for menopause: cardiovascular and skeletal muscle implications.Menopause (New York, N.Y.) 2018 · CEBM Level 5
- Nutritional ketosis delays the onset of isoflurane induced anesthesia.BMC anesthesiology 2018 · CEBM Level 5
- Corrigendum: Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.Frontiers in molecular neuroscience 2017 · CEBM Level 5
- Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 · CEBM Level 5
- Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.PloS one 2017 · CEBM Level 5
- Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats.Frontiers in molecular neuroscience 2016 · CEBM Level 5
- Impact of negative affectivity and trait forgiveness on aortic blood pressure and coronary circulation.Psychophysiology 2015 · CEBM Level 4
- Acute passive vibration reduces arterial stiffness and aortic wave reflection in stroke survivors.European journal of applied physiology 2014 · CEBM Level 2
- School burnout and cardiovascular functioning in young adult males: a hemodynamic perspective.Stress (Amsterdam, Netherlands) 2014 · CEBM Level 4
- Impact of acute whole-body cold exposure with concurrent isometric handgrip exercise on aortic pressure waveform characteristics.European journal of applied physiology 2014 · CEBM Level 2
- Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy.The Journal of biological chemistry 2014 · CEBM Level 5
- Depressive symptoms contribute to increased wave reflection during cold pressor test in young adult men.American journal of hypertension 2013 · CEBM Level 4
- The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise.American journal of hypertension 2013 · CEBM Level 2
- Sympathetic vasomotor tone is associated with depressive symptoms in young females: a potential link between depression and cardiovascular disease.American journal of hypertension 2013 · CEBM Level 4