Daniel Amen
Dr. Daniel Amen is a researcher and author working in the field of neuroimaging and psychiatric health. His published research focuses primarily on using brain single-photon emission computed tomography (SPECT) imaging to assess regional cerebral blood flow and neural connectivity. His work investigates functional brain imaging biomarkers across psychiatric and neurological conditions, including major depressive disorder, schizophrenia, ADHD, cognitive disorders, and the effects of adverse childhood experiences.
60 claims checked on air: 7 context 2 contradicted 6 overstated 36 supported 9 unverified
What they said on air - unverified
8 citing their own research
Tom Brady gets nine hours of sleep per night and avoids gluten, dairy, corn, soy, artificial dyes, sweeteners, and sugar.
"Gets nine hours of sleep, he doesn't eat gluten, dairy, corn, soy, artificial dyes, sweeteners, sugar. I mean, his diet is really clean" (said at 0:50:20)
No published record matching the specific daily sleep duration and dietary exclusions of Tom Brady was located in the scientific literature; this does not prove the claim false. While the described nutritional rules align broadly with public descriptions of the commercial "TB12 Method" lifestyle program, individual lifestyle regimens of specific athletes are not documented or evaluated in peer-reviewed biomedical research.
Former NFL player Ed White lost 150 pounds participating in Dr. Daniel Amen's NFL weight loss group.
"And we did an NFL weight loss group, which was so much fun for me. I had Big Ed White become Little Ed White. He lost 150 pounds, which was really fun." (said at 1:00:00)
No published record matching the claim that former NFL player Ed White lost 150 pounds in Dr. Daniel Amen's weight loss group was located; this does not prove the claim false. Dr. Amen published a study detailing an open-label multi-component intervention in 30 retired NFL players that included weight loss where appropriate (PMID 21615001), but individual player identities and specific weight loss figures such as 150 pounds were not reported in peer-reviewed publications.
The human brain consumes approximately 20% of the body's total blood flow and 20% of its oxygen.
"your brain uses 20% of the blood flow, 20% of the oxygen, and anything that damages your heart damages your brain." (said at 0:09:27)
No published record matching the claim that the human brain consumes approximately 20% of the body's total blood flow and 20% of its oxygen was located; this does not prove the claim false.
A clinic study of 50 consecutive psychiatric patients not taking fish oil found that 49 of them (98%) had suboptimal omega-3 index levels.
"And we did a study here last year where we looked at the omega-3 index on 50 consecutive patients who were not taking fish oil. 49 of them had suboptimal levels. Think about that: 98% of our population—now, we have a skewed population, no, but 98% of a complex psychiatric population has suboptimal levels of omega-3 fatty acids." (said at 0:19:26)
No published record matching a clinic study of 50 consecutive psychiatric patients finding that 49 of them (98%) had suboptimal omega-3 index levels was located; this does not prove the claim false. Although research from psychiatric clinical settings has evaluated omega-3 index levels in relation to cerebral blood flow and cognition, this specific 50-patient clinic audit has not been identified in peer-reviewed literature.
Beets and cayenne pepper have both been shown to increase blood flow.
"for blood flow, it's beets and cayenne pepper. Both of those have been shown to increase blood flow." (said at 0:27:20)
No published record matching the claim that beets and cayenne pepper have both been shown to increase blood flow was located; this does not prove the claim false.
Green tea extract and blueberry extract have been demonstrated to decrease beta-amyloid plaques.
"curcumin and vitamin D have been shown to decrease those plaques, as has green tea extract and blueberry extract." (said at 0:28:20)
No published record matching the claim that green tea extract and blueberry extract decrease beta-amyloid plaques was located; this does not prove the claim false.
Boxers carrying the APOE e4 gene show cognitive impairment after an average of 11 fights, whereas non-carriers do not show cognitive impairment until after approximately 30 fights.
"So boxers who have the E4 gene, so people have repetitive head trauma, they start to show cognitive impairment after their 11th fight, where those who don't have the E4 gene actually don't show cognitive impairment until after their 30th fight." (said at 0:28:35)
No published record matching the claim that boxers carrying the APOE e4 allele develop cognitive impairment after an average of 11 fights whereas non-carriers develop impairment after approximately 30 fights was located; this does not prove the claim false.
Individuals with untreated ADD use medical services at four times the rate of the general population.
"they use medical services four times the level of the general population" (said at 0:45:36)
No published record matching the claim that individuals with untreated ADD use medical services at four times the rate of the general population was located; this does not prove the claim false.
Kris Kristofferson was treated with antibiotics and hyperbaric oxygen for Lyme disease after being misdiagnosed, which allowed him to resume touring.
"And there's a story in the book about Kris Kristofferson, who saw one of our doctors... marked debilitating disease when in fact he had Lyme, and on an antibiotic and hyperbaric oxygen he went back on the road touring." (said at 0:50:20)
No published record matching the claim that Kris Kristofferson was diagnosed with Lyme disease and successfully treated with antibiotics and hyperbaric oxygen allowing him to resume touring was located in the peer-reviewed medical literature; this does not prove the claim false.
Fact-checked episodes
Publications
- Examining comorbid and transdiagnostic depression clinical outcomes across anxiety, autism, attention deficit hyperactivity disorder (ADHD), bipolar disorder, depression, and schizotypal personality groups: a novel NeuroMark SPECT approach.medRxiv : the preprint server for health sciences 2026 · CEBM Level 4
- A Replicable NeuroMark Template for Whole-Brain SPECT Reveals Data-Driven Perfusion Networks and Their Alterations in Schizophrenia.Neuroinformatics 2026 · CEBM Level 4
- Classifying schizophrenia patients and healthy individuals: Whole brain SPECT functional connectivity using support vector machine classification.Neuroimage. Reports 2026 · CEBM Level 4
- Functional vs Structural Cortical Deficit Pattern Biomarkers for Major Depressive Disorder.JAMA psychiatry 2025 · CEBM Level 4
- Predicting Regional Cerebral Blood Flow Using Voxel-Wise Resting-State Functional MRI.Brain sciences 2025 · CEBM Level 4
- A multi-site 99m Tc-HMPAO SPECT study of cerebral blood flow in a community sample of patients with major depression.Translational psychiatry 2024 · CEBM Level 4
- Adverse childhood experiences, brain function, and psychiatric diagnoses in a large adult clinical cohort.Frontiers in psychiatry 2024 · CEBM Level 4
- SPECT Functional Neuroimaging Distinguishes Adult Attention Deficit Hyperactivity Disorder From Healthy Controls in Big Data Imaging Cohorts.Frontiers in psychiatry 2021 · CEBM Level 4
- A New Way Forward: How Brain SPECT Imaging Can Improve Outcomes and Transform Mental Health Care Into Brain Health Care.Frontiers in psychiatry 2021 · CEBM Level 5
- Patterns of Regional Cerebral Blood Flow as a Function of Obesity in Adults.Journal of Alzheimer's disease : JAD 2020 · CEBM Level 4
- Deficits in Regional Cerebral Blood Flow on Brain SPECT Predict Treatment Resistant Depression.Journal of Alzheimer's disease : JAD 2018 · CEBM Level 4
- Patterns of Regional Cerebral Blood Flow as a Function of Age Throughout the Lifespan.Journal of Alzheimer's disease : JAD 2018 · CEBM Level 4
- Discriminative Properties of Hippocampal Hypoperfusion in Marijuana Users Compared to Healthy Controls: Implications for Marijuana Administration in Alzheimer's Dementia.Journal of Alzheimer's disease : JAD 2017 · CEBM Level 4
- Classification of Depression, Cognitive Disorders, and Co-Morbid Depression and Cognitive Disorders with Perfusion SPECT Neuroimaging.Journal of Alzheimer's disease : JAD 2017 · CEBM Level 4
- Quantitative Erythrocyte Omega-3 EPA Plus DHA Levels are Related to Higher Regional Cerebral Blood Flow on Brain SPECT.Journal of Alzheimer's disease : JAD 2017 · CEBM Level 4
- Gender-Based Cerebral Perfusion Differences in 46,034 Functional Neuroimaging Scans.Journal of Alzheimer's disease : JAD 2017 · CEBM Level 4
- Perfusion Neuroimaging Abnormalities Alone Distinguish National Football League Players from a Healthy Population.Journal of Alzheimer's disease : JAD 2016 · CEBM Level 4
- Functional neuroimaging with default mode network regions distinguishes PTSD from TBI in a military veteran population.Brain imaging and behavior 2015 · CEBM Level 4
- Functional Neuroimaging Distinguishes Posttraumatic Stress Disorder from Traumatic Brain Injury in Focused and Large Community Datasets.PloS one 2015 · CEBM Level 4
- Clinical comparison of 99mTc exametazime and 123I Ioflupane SPECT in patients with chronic mild traumatic brain injury.PloS one 2014 · CEBM Level 4
- Clinical utility of SPECT neuroimaging in the diagnosis and treatment of traumatic brain injury: a systematic review.PloS one 2014 · CEBM Level 1
- It's time to stop flying blind: how not looking at the brain leads to missed diagnoses, failed treatments, and dangerous behaviors.Alternative therapies in health and medicine 2013 · CEBM Level 4
- Multi-site six month outcome study of complex psychiatric patients evaluated with addition of brain SPECT imaging.Advances in mind-body medicine 2013 · CEBM Level 3
- Effects of brain-directed nutrients on cerebral blood flow and neuropsychological testing: a randomized, double-blind, placebo-controlled, crossover trial.Advances in mind-body medicine 2013 · CEBM Level 2
- Daniel Amen, MD: healing brain injury and damage from environmental toxins. Interviewed by Karen Burnett.Advances in mind-body medicine 2013 · CEBM Level 5
- A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder.Journal of neurotrauma 2012 · CEBM Level 4
- Daniel Amen, MD: the impact of brain imaging on psychiatry and treatment for improving brain health and function. Interview by Karen Burnett.Alternative therapies in health and medicine 2012 · CEBM Level 5
- The clinical utility of brain SPECT imaging in process addictions.Journal of psychoactive drugs 2012 · CEBM Level 5
- Specific ways brain SPECT imaging enhances clinical psychiatric practice.Journal of psychoactive drugs 2012 · CEBM Level 4
- Impact of playing American professional football on long-term brain function.The Journal of neuropsychiatry and clinical neurosciences 2011 · CEBM Level 4
- Elevated BMI is associated with decreased blood flow in the prefrontal cortex using SPECT imaging in healthy adults.Obesity (Silver Spring, Md.) 2011 · CEBM Level 4
- Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation.Journal of psychoactive drugs 2011 · CEBM Level 3
- Brain SPECT Imaging in Complex Psychiatric Cases: An Evidence-Based, Underutilized Tool.The open neuroimaging journal 2011 · CEBM Level 5
- Cerebral blood flow differences between long-term meditators and non-meditators.Consciousness and cognition 2010 · CEBM Level 4
- High resolution brain SPECT imaging in a clinical substance abuse practice.Journal of psychoactive drugs 2010 · CEBM Level 5
- Brain SPECT imaging in clinical practice.The American journal of psychiatry 2010 · CEBM Level 5
- Cerebral blood flow changes during chanting meditation.Nuclear medicine communications 2009 · CEBM Level 3
- A comparative analysis of completed suicide using high resolution brain SPECT imaging.The Journal of neuropsychiatry and clinical neurosciences 2009 · CEBM Level 4
- Omentum transposition surgery for patients with Alzheimer's disease: a case series.Neurological research 2008 · CEBM Level 4
- Predicting positive and negative treatment responses to stimulants with brain SPECT imaging.Journal of psychoactive drugs 2008 · CEBM Level 4
- Preliminary evidence differentiating ADHD using brain SPECT imaging in older patients.Journal of psychoactive drugs 2008 · CEBM Level 4
- An analysis of regional cerebral blood flow in impulsive murderers using single photon emission computed tomography.The Journal of neuropsychiatry and clinical neurosciences 2007 · CEBM Level 4
- High-resolution brain SPECT imaging and eye movement desensitization and reprocessing in police officers with PTSD.The Journal of neuropsychiatry and clinical neurosciences 2005 · CEBM Level 4