Estrogen, progesterone, and testosterone levels drop in women after ages 40 to 45.
"after 40, 45, we have to take care of our body because estrogen declines, progesterone drops, testosterone drops, everything drops" (said at 0:03:50)
The speaker's general assertion that key female sex hormones decline as women transition through their 40s and into menopause is broadly accurate, but the exact timing and trajectories differ by hormone. Progesterone declines during perimenopause (typically beginning in the 40s) due to an increasing frequency of anovulatory cycles and luteal phase deficiency. Estrogen (principally estradiol) undergoes wide, unpredictable fluctuations during early perimenopause before experiencing a steep and sustained drop in the late perimenopausal transition and postmenopause. In contrast, circulating testosterone declines steadily with age starting in early adulthood (falling by approximately 50% between ages 20 and 40), with relatively modest or stable changes specifically attributable to the menopausal transition itself.
- context: Hormonal changes in the menopause transition. (Recent progress in hormone research 2002)
"Estradiol levels remain relatively unchanged or tend to rise with age until the onset of the transition and are usually well preserved until the late perimenopause, presumably in response to the elevated FSH levels. During the transition, hormone levels frequently vary markedly - hence, measures of FSH and estradiol are unreliable guides to menopausal status. Concentrations of testosterone have been reported to fall by about 50% during reproductive life, between the ages of 20 and 40. They change little during the transition and, after menopause, may even rise." (abstract, results, passage verified)
pubmedfull study (doi) - context: A longitudinal study of the perimenopausal transition: altered profiles of steroid and pit… (Maturitas 2008)
"During the premenopausal period an increasing frequency of inadequate luteal function or anovulation occurred and, in the postmenopausal years, the serum levels of progesterone (P) were invariably low. Gradually, the ratio between estrone (E1) and 17-beta-estradiol (E2) increased, reflecting the declining follicular steroidogenesis. A marked decrease in estrogen levels occurred during the 6 month period around the menopause, most pronounced in E2... Around the menopause, serum levels of testosterone (T), delta4-androstenedione (A) and sex hormone-binding globulin (SHBG) showed small but significant decreases." (abstract, results, passage verified)
pubmedfull study (doi)