Dietary cholesterol has no long-term impact on serum cholesterol levels.
"We know that dietary cholesterol has no long-term impact on serum cholesterol, and so I implore people to make regular use of eggs." (said at 0:39:34)
The claim that dietary cholesterol has no impact on serum cholesterol levels is contradicted by systematic reviews and meta-analyses of randomized intervention trials. A meta-analysis of intervention trials found that increasing dietary cholesterol statistically significantly raised both total cholesterol (net change: 11.2 mg/dL) and LDL cholesterol (net change: 6.7 mg/dL), as well as HDL cholesterol. While the impact of dietary cholesterol on blood lipids is smaller and more variable between individuals than that of saturated fat, clinical trial evidence consistently demonstrates a modest, statistically significant elevation in circulating cholesterol concentrations in response to dietary cholesterol intake.
- contradicts: Dietary cholesterol and cardiovascular disease: a systematic review and meta-analysis. (The American journal of clinical nutrition 2015)
"Dietary cholesterol statistically significantly increased both serum total cholesterol (17 trials; net change: 11.2 mg/dL; 95% CI: 6.4, 15.9) and low-density lipoprotein (LDL) cholesterol (14 trials; net change: 6.7 mg/dL; 95% CI: 1.7, 11.7 mg/dL)." (abstract, results, passage verified)
pubmedfull study (doi) - contradicts: Dietary Cholesterol and Cardiovascular Risk: A Science Advisory From the American Heart As… (Circulation 2020)
"Although meta-analyses of intervention studies differ in their findings, most associate intakes of cholesterol that exceed current average levels with elevated total or low-density lipoprotein cholesterol concentrations." (abstract, results, passage verified)
pubmedfull study (doi)