Richard Horowitz
Richard Horowitz is a physician specializing in the diagnosis and treatment of Lyme disease, tick-borne coinfections, and chronic illness. His published research primarily focuses on treatment protocols for chronic Lyme disease and post-treatment Lyme disease syndrome, particularly evaluated through dapsone combination therapy regimens and the Multiple Systemic Infectious Disease Syndrome (MSIDS) model. Additionally, his work includes studies on diagnostic assays for babesiosis and clinical reports on therapies for COVID-19.
47 claims checked on air: 5 context 1 contradicted 8 overstated 19 supported 14 unverified
What they said on air - contradicted
6 citing their own research
Lecanemab lowered phosphorylated tau by 23% in clinical trials over nearly 7 years.
"And the drugs that are used for it, lecanemab, they lowered phosphorylated tau by 23% in almost 7 years." (said at 0:30:35)
The claim that lecanemab lowered phosphorylated tau by 23% over nearly 7 years is contradicted by clinical trial evidence. In the primary Phase 3 clinical trial (Clarity AD), lecanemab was evaluated over an 18-month (1.5-year) double-blind period, not 7 years. While lecanemab significantly reduced amyloid markers and slowed clinical decline compared with placebo at 18 months, published clinical trials and long-term pharmacodynamic modeling evaluate outcomes over 18 months to 4 years, making the claimed 7-year timeframe inaccurate.
- contradicts: Lecanemab in Early Alzheimer's Disease. (The New England journal of medicine 2023) · cited 5541x in the literature
"We conducted an 18-month, multicenter, double-blind, phase 3 trial involving persons 50 to 90 years of age with early Alzheimer's disease (mild cognitive impairment or mild dementia due to Alzheimer's disease) with evidence of amyloid on positron-emission tomography (PET) or by cerebrospinal fluid testing." (abstract, methods, passage verified)
pubmedfull study (doi) - contradicts: Pharmacokinetic/pharmacodynamic analyses of plasma pathophysiology biomarkers in subjects … (Alzheimer's & dementia (New York, N. Y.) 2026)
"Simulations were conducted to evaluate the effect of lecanemab (10 mg/kg IV every 2 weeks, LEC10-BW) after 4 years of continuous treatment, discontinuation after 18 months of treatment or transitioning to less frequent dosing at 18, 24, or 30 months." (abstract, methods, passage verified)
pubmedfull study (doi)
Fact-checked episodes
Publications
- Combining Double-Dose and High-Dose Pulsed Dapsone Combination Therapy for Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome and Co-Infections, Including Bartonella: A Report of 3 Cases and a Literature Review.Microorganisms 2024 · CEBM Level 4
- Comparison of the Efficacy of Longer versus Shorter Pulsed High Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome with Bartonellosis and Associated Coinfections.Microorganisms 2023 · CEBM Level 4
- Efficacy of Short-Term High Dose Pulsed Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-Infections: A Report of Three Cases and Literature Review.Antibiotics (Basel, Switzerland) 2022 · CEBM Level 4
- Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases.Respiratory medicine case reports 2020 · CEBM Level 4
- A Fluorescence in Situ Hybridization (FISH) Test for Diagnosing Babesiosis.Diagnostics (Basel, Switzerland) 2020 · CEBM Level 4
- Three novel prevention, diagnostic, and treatment options for COVID-19 urgently necessitating controlled randomized trials.Medical hypotheses 2020 · CEBM Level 5
- Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi.BMC research notes 2020 · CEBM Level 5
- Combined Immunofluorescence (IFA) and Fluorescence In Situ Hybridization (FISH) Assays for Diagnosing Babesiosis in Patients from the USA, Europe and Australia.Diagnostics (Basel, Switzerland) 2020 · CEBM Level 4
- Efficacy of Double-Dose Dapsone Combination Therapy in the Treatment of Chronic Lyme Disease/Post-Treatment Lyme Disease Syndrome (PTLDS) and Associated Co-infections: A Report of Three Cases and Retrospective Chart Review.Antibiotics (Basel, Switzerland) 2020 · CEBM Level 4
- Precision medicine: retrospective chart review and data analysis of 200 patients on dapsone combination therapy for chronic Lyme disease/post-treatment Lyme disease syndrome: part 1.International journal of general medicine 2019 · CEBM Level 4
- Improvement of common variable immunodeficiency using embryonic stem cell therapy in a patient with lyme disease: a clinical case report.Clinical case reports 2018 · CEBM Level 4
- Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2.Healthcare (Basel, Switzerland) 2018 · CEBM Level 4
- Empirical validation of the Horowitz Multiple Systemic Infectious Disease Syndrome Questionnaire for suspected Lyme disease.International journal of general medicine 2017 · CEBM Level 4
- Approach to diagnosing Lyme disease misses a large proportion of cases.BMJ (Clinical research ed.) 2016 · CEBM Level 5
- Rash decisions about southern tick-associated rash illness and Lyme disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2006 · CEBM Level 5
- Coinfection with Borrelia burgdorferi and Babesia microti: bad or worse?The Journal of infectious diseases 2006 · CEBM Level 5
- Lyme disease testing.The Lancet. Infectious diseases 2006 · CEBM Level 5
- Possible role of tick-borne infection in "cat-scratch disease": comment on the article by Giladi et al.Arthritis and rheumatism 2006 · CEBM Level 5
- Lyme disease: scratching the surface.Lancet (London, England) 2005 · CEBM Level 5
- Evidence-based guidelines for the management of Lyme disease.Expert review of anti-infective therapy 2004 · CEBM Level 5