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Steve Horvath

Steve Horvath is a researcher in biogerontology and the biology of aging. His published research primarily focuses on the development and application of epigenetic clocks and DNA methylation biomarkers to assess biological age across humans and diverse animal species. He also studies the effects of longevity interventions, calorie restriction, and the relationships between epigenetic age acceleration and conditions such as cognitive decline and cancer.

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0:59:23supportedlowtheir own paperDr. Steve Horvath on epigenetic aging to predict healthspan:

In an observational analysis from the Women's Health Initiative cohort, fish oil/omega-3 supplementation was associated with slower epigenetic aging according to the GrimAge clock.

"Interestingly, according to GrimAge, we did find that people who used omega-3 supplements or fish oil, they were actually aging more slowly. ... we analyzed really an observational study, and that's our problem: our study was an epidemiological study, I want to say the Women's Health Initiative. And and there we did see this association that women who took fish oil supplements were aging more slowly according to GrimAge, you know." (said at 0:59:23)

In the landmark study introducing the DNAm GrimAge epigenetic clock (Lu et al., 2019), the investigators analyzed large cohort datasets including the Women's Health Initiative (WHI) and the Framingham Heart Study to evaluate cross-sectional associations between lifestyle factors, dietary supplement use, and epigenetic age acceleration. They identified an association between omega-3/fish oil supplementation and negative GrimAge acceleration (slower biological aging relative to chronological age). Subsequent randomized clinical trial data (such as the DO-HEALTH trial) and Mendelian randomization studies have similarly observed that omega-3 intake or supplementation is associated with deceleration across second-generation DNA methylation clocks, including GrimAge.

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