HoldsUp

Steve Horvath

Steve Horvath is a researcher in biogerontology and the biology of aging. His published research primarily focuses on the development and application of epigenetic clocks and DNA methylation biomarkers to assess biological age across humans and diverse animal species. He also studies the effects of longevity interventions, calorie restriction, and the relationships between epigenetic age acceleration and conditions such as cognitive decline and cancer.

41 claims checked on air: 2 context 35 supported 4 unverified

What they said on air - unverified

1 citing their own research

0:06:39unverifiedvery lowDr. Steve Horvath on epigenetic aging to predict healthspan:

The heritability of the epigenetic aging clock rate is approximately 40 percent.

"So some people just inherit a genome that makes, or DNA that really allows the epigenetic clock to progress more slowly, and so the heritability is about 40%, you know." (said at 0:06:39)

No published record matching the claim that the heritability of the epigenetic aging clock rate is approximately 40 percent was located; this does not prove the claim false.

0:10:43unverifiedvery lowDr. Steve Horvath on epigenetic aging to predict healthspan:

DNA methylation patterns are significantly more stable than gene expression, proteomics, and metabolomics measurements.

"So when we compare to any other genomic measurement, I mean, they would be far more stable than anything I'm aware of. They're far more stable than gene expression, proteomics, metabolomics measurements. All the omics are less stable, you know." (said at 0:10:43)

No published record matching the comparative stability of DNA methylation patterns relative to gene expression, proteomics, and metabolomics measurements was located; this does not prove the claim false.

0:30:28unverifiedvery lowDr. Steve Horvath on epigenetic aging to predict healthspan:

Blood cells have fewer estrogen receptors compared to buccal epithelial cells.

"blood cells don't have as many estrogen receptors as buccal epithelial cells." (said at 0:30:28)

No published record matching the claim that blood cells have fewer estrogen receptors compared to buccal epithelial cells was located; this does not prove the claim false. While both peripheral blood leukocytes and buccal mucosal epithelial cells are known to express estrogen receptors (such as ERα and ERβ), direct comparative quantification of receptor density between these two specific cell types has not been established in the indexed biomedical literature.

0:39:11unverifiedvery lowDr. Steve Horvath on epigenetic aging to predict healthspan:

The original pan-tissue epigenetic clock accurately tracks gestational age during development in prenatal brain samples, 3D brain organoids, and retina samples.

"my original pan-tissue epigenetic clock works actually beautifully in prenatal brain samples, it works beautifully in in various in vitro studies of so-called three-dimensional brains, you know, or in or in retina samples. So really it captures aging of gestational age during development, you know." (said at 0:39:11)

No published record matching the claim that the original pan-tissue epigenetic clock accurately tracks gestational age during development in prenatal brain samples, 3D brain organoids, and retina samples was located; this does not prove the claim false.

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