Tom Segura
Tom Segura is a featured guest on the podcast episode 'Mostly Wise #1'. During this appearance, he participates in discussions covering topics such as tadalafil, artificial intelligence clones, lawsuits, and popular culture. The provided context does not list any formal research publications or academic background.
4 claims checked on air: 1 context 1 contradicted 2 supported 1 flagged
What they said on air - supported
Tadalafil causes vasodilation that slightly lowers blood pressure.
"And it can and it can disrupt, you know, lower blood pressure slightly and things like that cuz you you get in vasodilation, so you know, all the pipes are getting a little bigger." (said at 0:02:32)
Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor that promotes vascular smooth muscle relaxation and vasodilation via cyclic guanosine monophosphate (cGMP) accumulation. Extensive clinical trial data show that tadalafil exerts mild vasodilatory effects leading to slight, transient reductions in systolic and diastolic blood pressure in both healthy individuals and patients with cardiovascular conditions.
- supports: Pharmacokinetics, pharmacodynamics, and efficacy of phosphodiesterase type 5 inhibitors. (The Journal of the American Osteopathic Association 2004) · cited 33x in the literature
"However, as mild vasodilators, the PDE5 inhibitors are also associated with hemodynamic effects that may be clinically significant, especially when treating men with ED who have comorbid cardiovascular disease. Hemodynamic studies have shown that therapeutic dosages of the PDE5 inhibitors produce only mild and transient changes in mean systolic and diastolic blood pressure and heart rate in healthy men as well as those with ischemic heart disease or chronic stable angina." (abstract, results, passage verified)
pubmed - supports: Phosphodiesterase-5 inhibitors and their hemodynamic effects. (Current hypertension reports 2006) · cited 28x in the literature
"Phosphodiesterase type 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, provide effective treatment of erectile dysfunction. They reduce blood pressure in healthy patients: sildenafil 100 mg, -3.7/-3.6 mm Hg; vardenafil 20 mg, -7.5/-8 mm Hg; and tadalafil 20 mg, -1.6/-0.8 mm Hg." (abstract, results, passage verified)
pubmedfull study (doi)
Creatine is used as a cutting agent or adulterant in illicit cocaine.
"You used to cut cocaine with creatine, right? Used to they would cut cocaine with creatine. Really? It's a cut, yeah." (said at 2:07:47)
Chemical and forensic analyses of illicit drug supplies consistently confirm that creatine is used as a cutting agent (diluent/adulterant) in street and online cocaine samples, alongside other typical adulterants such as caffeine, levamisole, lidocaine, lactose, and mannitol.
- supports: Adulteration and substitution of drugs purchased in Australia from cryptomarkets: An analy… (Drug and alcohol review 2024) · cited 18x in the literature
"Only 4 samples sold as cocaine contained solely the advertised substance, with 13 containing cocaine with adulterants like lidocaine, creatine, levamisole and boric acid (n = 19)." (abstract, results, passage verified)
pubmedfull study (doi) - supports: Non-destructive forensic identification and quantification of cocaine through sealed packa… (Analytica chimica acta 2026)
"Real samples of cocaine seized in four independent operations, together with six typical adulterants (creatine, caffeine, levamisole, lidocaine, lactose, and mannitol), were analyzed without opening the evidence" (abstract, results, passage verified)
pubmedfull study (doi)
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