HoldsUp

Roger Seheult

MedCram Videos

Roger Seheult is a physician, educator, and co-founder of MedCram Videos who has treated patients during the COVID-19 pandemic. His published research includes cost-effectiveness evaluations of vilobelimab for mechanically ventilated COVID-19 patients. Additionally, his work has examined the physiological effects of prophylactic bosentan on pulmonary artery pressure and exercise capacity at high altitude.

49 claims checked on air: 3 context 3 contradicted 2 overstated 33 supported 8 unverified 5 flagged

What they said on air - context

1:23:33needs contexthighDr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin

Aspirin was discovered in 1899 by the German company Bayer.

"Aspirin had just been discovered in 1899 uh by the German company Bayer." (said at 1:23:33)

The year 1899 marks when the German company Bayer registered the trademark "Aspirin" and launched the drug commercially, rather than its chemical discovery. The compound, acetylsalicylic acid, was first synthesized in 1853 by French chemist Charles Frédéric Gerhardt, and pure acetylsalicylic acid was synthesized at Bayer's laboratories on August 10, 1897.

1:32:23needs contextmoderateDr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin

Vasoconstriction caused by cold exposure triggers demargination of leukocytes into the circulation.

"when you just like we know when you take a cold shower that vasoconstriction causes demargination of leukocytes and that causes the amount of leukocytes in solution if you will or in the in the vasculature to go through find the viral particles and report to their lymph nodes" (said at 1:32:23)

Acute cold exposure (such as cold-water immersion or cold ambient air) triggers sympathetic nervous system activation, resulting in surges of catecholamines (norepinephrine and epinephrine) and cortisol that cause a transient mobilization (demargination) and increase in circulating leukocytes and granulocytes. However, this demargination is primarily mediated by catecholamine signaling and hemodynamic shear forces acting on vascular endothelial adhesion molecules, rather than peripheral vasoconstriction itself directly dislodging white blood cells. Furthermore, while circulating immune cell counts transiently rise following cold stress, clinical evidence does not demonstrate that taking a cold shower meaningfully enhances antiviral surveillance or active viral clearance in lymph nodes.

1:54:40needs contexthighDr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin

N-acetylcysteine (NAC) functions as an antioxidant and recycles the glutathione peroxidase system to mitigate oxidative stress.

"NAC is a great antioxidant. It's packed with antioxidants and it it's recycles that the the glutathione peroxidase system which is helpful in dealing with oxidative stress." (said at 1:54:40)

N-acetylcysteine (NAC) functions as an antioxidant and precursor for intracellular glutathione (GSH) synthesis, helping cells counteract oxidative stress. However, the claim's description of its mechanism needs qualification: NAC is a single amino acid derivative (a cysteine prodrug) rather than something "packed with antioxidants," and it does not directly recycle the glutathione peroxidase enzyme. Glutathione peroxidase utilizes reduced glutathione (GSH) to detoxify peroxides, producing glutathione disulfide (GSSG), which is subsequently reduced back to GSH by glutathione reductase. NAC supports this system by supplying cysteine to replenish GSH pools rather than directly recycling the peroxidase system.

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